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1

Neurocognitive deficits in children with sickle cell disease are associated with the severity of anemia

Channa T. Hijmans, Martha A. Grootenhuis, Jaap Oosterlaan, Harriët Heijboer, Marjolein Peters, Karin Fijnvandraat

Journal:

Pediatric Blood & Cancer

Year:

2011

Language:

english

File:

PDF, 98 KB

english, 2011

2

Applications of random sampling to virtual screening of combinatorial libraries

Paul Beroza, Erin K. Bradley, John E. Eksterowicz, Robert Feinstein, Jonathan Greene, Peter D.J. Grootenhuis, Randal M. Henne, John Mount, William A. Shirley, Andrew Smellie, Robert V. Stanton, David

Journal:

Journal of Molecular Graphics and Modelling

Year:

2000

Language:

english

File:

PDF, 858 KB

english, 2000

3

Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

Jan Kelder, Peter D. J. Grootenhuis, Denis M. Bayada, Leon P. C. Delbressine, Jan-Peter Ploemen

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 850 KB

1999

4

Male gender, school attendance and sports participation are positively associated with health-related quality of life in children and adolescents with congenital bleeding disorders

Limperg, P. F., Joosten, M. M. H., Fijnvandraat, K., Peters, M., Grootenhuis, M. A., Haverman, L.

Journal:

Year:

2018

Language:

english

File:

PDF, 409 KB

english, 2018

5

Computer simulations of the dynamics of human choriogonadotropin and its α subunit

Milou L.C.E. Kouwijzer, Herman J.C. Berendsen, Peter D.J. Grootenhuis

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1999

Language:

english

File:

PDF, 680 KB

english, 1999

6

A Method To Identify and Screen Libraries of Guests That Complex to a Synthetic Host

Menno R. de Jong, Ronald M. A. Knegtel, Peter D. J. Grootenhuis, Jurriaan Huskens, David N. Reinhoudt

Journal:

Angewandte Chemie

Year:

2002

Language:

english

File:

PDF, 147 KB

english, 2002

7

A Method To Identify and Screen Libraries of Guests That Complex to a Synthetic Host

Menno R. de Jong, Ronald M. A. Knegtel, Peter D. J. Grootenhuis, Jurriaan Huskens, David N. Reinhoudt

Journal:

Angewandte Chemie International Edition

Year:

2002

Language:

english

File:

PDF, 147 KB

english, 2002

8

Free energy calculation on base specificity of drug – DNA interactions: Application to daunomycin and acridine intercalation into DNA

Piotr Cieplak, Shashidhar N. Rao, Peter D. J. Grootenhuis, Peter A. Kollman

Journal:

Year:

1990

Language:

english

File:

PDF, 865 KB

english, 1990

9

Water-Soluble Molecular Capsules: Self-Assembly and Binding Properties

Francesca Corbellini, Ronald M. A. Knegtel, Peter D. J. Grootenhuis, Mercedes Crego-Calama, David N. Reinhoudt

Journal:

Chemistry - A European Journal

Year:

2005

Language:

english

File:

PDF, 435 KB

english, 2005

10

ChemInform Abstract: Novel Acylguanidine Containing Thrombin Inhibitors with Reduced Basicity at the P1 Moiety.

Anton E. P. Adang, Hans Lucas, Adrianus P. A. de Man, Richard A. Engh, Peter D. J. Grootenhuis

Journal:

Year:

1999

File:

PDF, 34 KB

1999

11

ChemInform Abstract: Kinetic Resolutions and Enantioselective Transformations of 5-(Acyloxy)pyrrolinones Using Candida antarctica Lipase B: Synthetic and Structural Aspects.

Agnes D. Cuiper, Milou L. C. E. Kouwijzer, Peter D. J. Grootenhuis, Richard M. Kellogg, Ben L. Feringa

Journal:

Year:

2000

File:

PDF, 34 KB

2000

12

Peptide-derived transition state analogue inhibitors of thrombin; Synthesis, activity and selectivity

Mieke Jetten, Co A.M. Peters, Arie Visser, Peter D.J. Grootenhuis, Jan W. van Nispen, Harry C.J. Ottenheijm

Journal:

Bioorganic & Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.40 MB

english, 1995

13

Design of a gene family screening library targeting G-protein coupled receptors

Michelle L. Lamb, Erin K. Bradley, Graham Beaton, Steven S. Bondy, Angelo J. Castellino, Paul A. Gibbons, Mark J. Suto, Peter D.J. Grootenhuis

Journal:

Journal of Molecular Graphics and Modelling

Year:

2004

Language:

english

File:

PDF, 247 KB

english, 2004

14

Intraannular functionalization of macrocyclic polyethers via organolithium chemistry; x-ray structure of 2-sulfinyl-1,3-xylyl-15-crown-4

Maria Skowronska-Ptasinska, Pieter Telleman, Veronika M.L.J Aarts, Peter D.J Grootenhuis, Johan van Eerden, Sybolt Harkema, David N Reinhoudt

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 280 KB

english, 1987

15

Novel acylguanidine containing thrombin inhibitors with reduced basicity at the P1 moiety

Anton E.P. Adang, Hans Lucas, Adrianus P.A. de Man, Richard A. Engh, Peter D.J. Grootenhuis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 347 KB

english, 1998

16

(Q) SAR study on the metabolic stability of steroidal androgens

Roberta Bursi, Marcel E de Gooyer, Arijan Grootenhuis, Peter L Jacobs, Jaap van der Louw, Dirk Leysen

Journal:

Journal of Molecular Graphics and Modelling

Year:

2001

Language:

english

File:

PDF, 76 KB

english, 2001

17

Behavioral and emotional problems in children with sickle cell disease and healthy siblings: Multiple informants, multiple measures

Channa T. Hijmans, Martha A. Grootenhuis, Jaap Oosterlaan, Bob F. Last, Harriët Heijboer, Marjolein Peters, Karin Fijnvandraat

Journal:

Pediatric Blood & Cancer

Year:

2009

Language:

english

File:

PDF, 102 KB

english, 2009

18

Neurocognitive deficits in children with sickle cell disease: a comprehensive profile

Channa T. Hijmans, Karin Fijnvandraat, Martha A. Grootenhuis, Nan van Geloven, Harriët Heijboer, Marjolein Peters, Jaap Oosterlaan

Journal:

Pediatric Blood & Cancer

Year:

2011

Language:

english

File:

PDF, 121 KB

english, 2011

19

Macrocyclic receptor molecules with a pendant carboxylic acid group for the complexation of urea

Veronika M. L. J. Aarts, Peter D. J. Grootenhuis, David N. Reinhoudt, Anna Czech, Bronislaw P. Czech, Richard A. Bartsch

Journal:

Recueil des Travaux Chimiques des Pays-Bas

Year:

1988

Language:

english

File:

PDF, 1.06 MB

english, 1988

20

Homology model-building studies of human thrombin: Optimisation of modelling protocol and comparison with X-ray structure

Luc M. H. Koymans, Peter D. J. Grootenhuis, Cornelis A. G. Haasnoot

Journal:

Recueil des Travaux Chimiques des Pays-Bas

Year:

1993

Language:

english

File:

PDF, 1.20 MB

english, 1993

21

Finding potential DNA-binding compounds by using molecular shape

Peter D. J. Grootenhuis, Diana C. Roe, Peter A. Kollman, Irwin D. Kuntz

Journal:

Journal of Computer-Aided Molecular Design

Year:

1994

Language:

english

File:

PDF, 1.23 MB

english, 1994

22

Functionality map analysis of the active site cleft of human thrombin

Peter D. J. Grootenhuis, Martin Karplus

Journal:

Journal of Computer-Aided Molecular Design

Year:

1996

Language:

english

File:

PDF, 4.04 MB

english, 1996

23

Thermodynamic stabilities of complexes of synthetic macrocyclic valinomycin mimics with alkali, barium, and guanidinium cations

Peter D.J. Grootenhuis, Peter D. Van Der Wal, David N. Reinhoudt

Journal:

Year:

1987

Language:

english

File:

PDF, 599 KB

english, 1987

24

Coupling structure-based design with combinatorial chemistry: application of active site derived pharmacophores with informative library design

John E. Eksterowicz, Erik Evensen, Christian Lemmen, G. Patrick Brady, J. Kevin Lanctot, Erin K. Bradley, Eddine Saiah, Leslie A. Robinson, Peter D.J. Grootenhuis, Jeffrey M. Blaney

Journal:

Journal of Molecular Graphics and Modelling

Year:

2002

Language:

english

File:

PDF, 345 KB

english, 2002

25

Structure-based design and protein engineering of intersubunit disulfide bonds in gonadotropins

Heikoop, Judith C., Boogaart, Paul van den, Mulders, John WM, Grootenhuis, Peter D.J.

Journal:

Nature Biotechnology

Year:

1997

File:

PDF, 664 KB

1997

26

The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions

Schreuder, Herman A., de Boer, Bijtske, Dijkema, Rein, Mulders, John, Theunissen, Henri J. M., Grootenhuis, Peter D. J., Hol, Wim G. J.

Journal:

Natural Structural Biology

Year:

1994

File:

PDF, 1.24 MB

1994

27

Rational design of synthetic heparin analogues with tailor-made coagulation factor inhibitory activity

Grootenhuis, Peter D.J., Westerduin, Pieter, Meuleman, Dick, Petitou, Maurice, van Boeckel, Constant A.A.

Journal:

Natural Structural Biology

Year:

1995

File:

PDF, 439 KB

1995

28

Comparative molecular field analysis and energy interaction studies of thrombin-inhibitor complexes

Roberta Bursi, Peter D.J. Grootenhuis

Journal:

Journal of Computer-Aided Molecular Design

Year:

1999

Language:

english

File:

PDF, 164 KB

english, 1999

29

Comparison of two implementations of the incremental construction algorithm in flexible docking of thrombin inhibitors

Ronald M.A. Knegtel, Denis M. Bayada, Richard A. Engh, Wolfgang von der Saal, Vincent J. van Geerestein, Peter D.J. Grootenhuis

Journal:

Journal of Computer-Aided Molecular Design

Year:

1999

Language:

english

File:

PDF, 161 KB

english, 1999

30

Complexes of macrocyclic polyethers and neutral guest molecules: a systematic approach to the complexation of water molecules by 2,6-pyridinium crown ethers

Grootenhuis, Peter D. J., Uiterwijk, Jos W. H. M., Reinhoudt, David N., Van Staveren, Catherina J., Sudholter, Ernst J. R., Bos, Martinus., Van Eerden, Johan., Klooster, Wim T., Kruise, Laminus., Hark

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 1.23 MB

english, 1986

31

Reporting health-related quality of life scores to physicians during routine follow-up visits of pediatric oncology patients: Is it effective?

Vivian Engelen, Symone Detmar, Hendrik Koopman, Heleen Maurice-Stam, Huib Caron, Peter Hoogerbrugge, R. Maarten Egeler, Gertjan Kaspers, Martha Grootenhuis

Journal:

Pediatric Blood & Cancer

Year:

2012

Language:

english

File:

PDF, 208 KB

english, 2012

32

Molecular modelling and drug design: edited by J. G. Vinther and M. Gardner, MacMillan Press, 1994. UK£65.00 (xi + 444 pages) ISBN 0 333 57810 4

Peter D.J. Grootenhuis

Journal:

Trends in Biotechnology

Year:

1994

Language:

english

File:

PDF, 107 KB

english, 1994

33

Carbohydrates and drug discovery — the role of computer simulation

Peter D.J. Grootenhuis, Constant A.A. van Boeckel, Cornelis A.G. Haasnoot

Journal:

Trends in Biotechnology

Year:

1994

Language:

english

File:

PDF, 2.18 MB

english, 1994

34

Conformational analysis of the trimannose Manα(1 → 2)[Manα(1 → 6)]Manβ using the CHEAT95 force field; evaluation of the additivity principle

Milou L.C.E. Kouwijzer, Robert Schrijvers, Cornelis A.G. Haasnoot, Peter D.J. Grootenhuis

Journal:

Journal of Molecular Structure: THEOCHEM

Year:

1997

Language:

english

File:

PDF, 914 KB

english, 1997

35

High throughput P450 inhibition screens in early drug discovery

Gregor Zlokarnik, Peter D.J. Grootenhuis, John B. Watson

Journal:

Drug Discovery Today

Year:

2005

Language:

english

File:

PDF, 220 KB

english, 2005

36

Priority paper Partially deglycosylated human choriogonadotropin, stabilized by intersubunit disulfide bonds, shows full bioactivity

Judith C. Heikoop, Paul van den Boogaart, Renato de Leeuw, Ursula M. Rose, John W. M. Mulders, Peter D. J. Grootenhuis

Journal:

Year:

1998

Language:

english

File:

PDF, 106 KB

english, 1998

37

Expression of a bioactive, single-chain choriogonadotropin in Dictyostelium discoideum

Judith C. Heikoop, Peter D. J. Grootenhuis, Mieke Blaauw, Jacob S. Veldema, Peter J. M. Van Haastert, Maarten H. K. Linskens

Journal:

Year:

1998

Language:

english

File:

PDF, 161 KB

english, 1998

38

Towards minimized gonadotropins with full bioactivity

Judith C. Heikoop, Bianca Huisman-de Winkel, Peter D. J. Grootenhuis

Journal:

Year:

1999

Language:

english

File:

PDF, 298 KB

english, 1999

39

Evaluation of Subunit Truncation and the Nature of the Spacer for Single Chain Human Gonadotropins

Judith C. Heikoop, Miranda M. J. A. C. M. Van Beuningen-De Vaan, Paul Van Den Boogaart, Peter D. J. Grootenhuis

Journal:

Year:

1997

Language:

english

File:

PDF, 778 KB

english, 1997

40

The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa

Maurits J.M Burgering, Leon P.M Orbons, Antoon van der Doelen, John Mulders, Henri J.M Theunissen, Peter D.J Grootenhuis, Wolfram Bode, Robert Huber, Milton T Stubbs

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 949 KB

english, 1997

41

A semiquantitative food frequency questionnaire for use in epidemiologic research among the elderly: Validation by comparison with dietary history

Peter A. Grootenhuis, Susanne Westenbrink, Claudia M.T.L. Sie, J.Nico D. De Neeling, Frans J. Kok, Lex M. Bouter

Journal:

Journal of Clinical Epidemiology

Year:

1995

Language:

english

File:

PDF, 1000 KB

english, 1995

42

Structure–activity relationship study of human liver microsomes-catalyzed hydrolysis rate of ester prodrugs of MENT by comparative molecular field analysis (CoMFA)

Roberta Bursi, Arijan Grootenhuis, Jaap van der Louw, Jos Verhagen, Marcel de Gooyer, Peter Jacobs, Dirk Leysen

Journal:

Year:

2003

Language:

english

File:

PDF, 287 KB

english, 2003

43

Expression of biologically active fusion genes encoding the common α subunit and either the CGβ or FSHβ subunits: role of a linker sequence

Tadashi Sugahara, Peter D.J. Grootenhuis, Asomi Sato, Masataka Kudo, David Ben-Menahem, Mary R. Pixley, Aaron J.W. Hsuen, Irving Boime

Journal:

Molecular and Cellular Endocrinology

Year:

1996

Language:

english

File:

PDF, 772 KB

english, 1996

44

A Computational Ensemble Pharmacophore Model for Identifying Substrates of P-Glycoprotein

Penzotti, Julie E., Lamb, Michelle L., Evensen, Erik, Grootenhuis, Peter D. J.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 76 KB

english, 2002

45

Specificity in the recognition process between charged carbohydrates and proteins

Constant A.A. Van Boeckel, Peter D.J. Grootenhuis, Cornelis A.G. Haasnoot

Journal:

Trends in Pharmacological Sciences

Year:

1991

Language:

english

File:

PDF, 403 KB

english, 1991

46

In silico prediction of drug safety: despite progress there is abundant room for improvement

William J. Egan, Gregor Zlokarnik, Peter D.J. Grootenhuis

Journal:

Drug Discovery Today: Technologies

Year:

2004

Language:

english

File:

PDF, 165 KB

english, 2004

47

Double disadvantage: a case control study on health-related quality of life in children with sickle cell disease

Channa T Hijmans, Karin Fijnvandraat, Jaap Oosterlaan, Harriët Heijboer, Marjolein Peters, Martha A Grootenhuis

Journal:

Health and Quality of Life Outcomes

Year:

2010

Language:

english

File:

PDF, 318 KB

english, 2010

48

Computational study of the structural, energetic, and acid-base properties of calix[4]arenes

Grootenhuis, Peter D. J., Kollman, Peter A., Groenen, Leo C., Reinhoudt, David N., Van Hummel, Gerrit J., Ugozzoli, Franco, Andreetti, Giovanni D.

Journal:

Journal of the American Chemical Society

Year:

1990

Language:

english

File:

PDF, 1.54 MB

english, 1990

49

Crown ether mediated transport of guanidinium thiocyanate through a bulk liquid membrane and the correlation with the complex stability constants

Stolwijk, Theodorus B., Grootenhuis, Peter D. J., Van der Wal, Peter D., Sudholter, Ernst J. R., Reinhoudt, David N., Harkema, Sybolt, Uiterwijk, Jos W. H. M., Kruise, Laminus

Journal:

Journal of Organic Chemistry

Year:

1986

Language:

english

File:

PDF, 1.07 MB

english, 1986

50

Performance of 3D-Database Molecular Docking Studies into Homology Models

Oshiro, Connie, Bradley, Erin K., Eksterowicz, John, Evensen, Erik, Lamb, Michelle L., Lanctot, J. Kevin, Putta, Santosh, Stanton, Robert, Grootenhuis, Peter D. J.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 49 KB

english, 2004